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KMID : 1134820130420040595
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 4 p.595 ~ p.599
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Effects of Gastrodia elata Extracts on Scopolamine-induced Memory Impairment in Rats
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Kim Jin-Ho
Chu Han-Na
Park Eun-Hye
Jeong Jong-Gil
Kim Kyeong-Ok
Kim Jeong-Sang
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Abstract
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Alzheimer's disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with a localized loss of neurons mainly in the hippocampus and basal forebrain. This study investigated the neuroprotective effect of Gastrodia elata aqueous extracts against scopolamine-induced neurotoxicity in the hippocampus of male Sprague-Dawley rats. The animals (n=25) were divided into five different groups with five animals per each group. The normal group (Nor) was administered with saline, while the control (Con) group was administered saline after scopolamine treatment. The experimental group (Exp) was administered Gastrodia elata aqueous extracts (200 mg/kg body weight) for 20 or 30 days after scopolamine treatment. From a light microscopy study, the nuclei of neurons in the hippocampus were more shrunken or condensed in the 20 or 30 day control groups compared to experimental groups. The densities of neurons from the CA1 and CA3 area of the hippocampus in the Exp increased compared with the Con. Amyloid β protein, containing PAS-positive materials, was lower in the Exp compared with the Con. The present study demonstrates that Gastrodia elata aqueous extracts possess neuroprotective potential, thus validating its use in alleviating the toxic effects of scopolamine.
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KEYWORD
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Gastrodia elata, hippocampus, scopolamine
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